منابع مشابه
Effect of diethylstilbestrol on skin sterols of the male rat.
Diethylstilbestrol (DES) was injected in doses ranging from 600 micro g to 0.4 micrograms/kg body weight into mature male rats over a 3 wk period. Profound effects on skin morphology and on sterol content of skin were noted. The sebaceous glands atrophied and the epidermis lost granularity. The concentrations of all skin sterols, with the exception of cholesterol, were reduced. At a dose level ...
متن کاملSkin sterols. XII. Contrasting effects of certain mercaptans, amines, and related compounds on sterols and sebaceous glands.
The application of carcinogenic hydrocarbons to skin results in a rapid destruction of the seba ceous glands (3, 7, 13), and it has been suggested that a histological screening test for carcinogens might be based upon this phenomenon (13). Inde pendent studies on skin sterols have revealed that the application of carcinogens to rodent skin de creases the amount of A7-cholestenol in the epider m...
متن کاملSkin sterols. VIII. Effects of carcinogens, co-carcinogens, and of certain hyperplastic agents.
S Published with the approval of the director of the Wiscon sin Agricultural Experiment Station. Supported in part by the Jonathan Bowman fund, and by grant C-2177, National Insti tutes of Health, US. Public Health Service. Presented in part before the American Society of BiologicalChemists, Atlantic City, April 13, 1954 (Fed. Proc., 13:238, 1954). t PublicHealthresearchfellowof the NationalCan...
متن کاملExcretion of sterols from the skin of normal and hypercholesterolemic humans. Implications for sterol balance studies.
The 24 hr sterol excretion from the entire skin surface was determined in six normal and five hypercholesterolemic (Type II) patients fed a controlled, eucaloric diet containing 400 mg of plant sterols. All subjects received radiolabeled cholesterol intravenously in order to measure cholesterol turnover and exchange. The 24 hr skin surface lipids were collected subsequently at intervals of 7-10...
متن کاملEffects of hormonal factors and of the hereditary character hairless on the sterols of mouse skin.
The sterol A7-cholestenol constitutes a large proportion of the total sterols of rat and mouse skin (5, 7, 18). Whereas the concentration of this sterol is not altered by such factors as diet, metabolic rate (7), and ultraviolet light (13), it decreases rapidly following the application of carcinogenic hydrocarbons to mouse skin (5). This decrease coincides with destruction of the sebaceous gla...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1952
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)55769-0